Vaccine against canine leishmaniasis
Safety
Excellent tolerability shown in a wide range of breeds and ages.
Efficacy
72% prevention of canine leishmaniasis in areas at high risk of infection by Leishmania infantum.
Convenience
A single annual dose confers immunity for 365 days.
Speed
Protection against development of the disease from 28 days after vaccination.
Reliability
Specific immune response to vaccination that does not interfere with the serological diagnosis of the disease.
Efficacy confirmed in laboratory studies
Different laboratory studies conducted with experimental infection with Leishmania infantum showed that LetiFend®:
- Reduces development of the disease.
- Reduces clinical signs.
- Reduces parasite load in the spleen and lymph glands.
- Protects from 28 days.
- Duration of immunity: 1 year.
LetiFend® reduces the risk of developing clinical leishmaniasis
A dog vaccinated with LetiFend® presents:
Vaccination with LetiFend® does not interfere with the diagnosis of leishmaniasis
LetiFend®, a DIVA (Differentiating Infected from Vaccinated Animals) vaccine which allows discrimination between vaccinated and infected animals.
- Serums of animals vaccinated with LetiFend® were subject to the serological tests most widely used for the diagnosis of Leishmaniasis (ELISA, IIF and snap tests).
- The results showed that none of the evaluated tests were positive after analysis of the serums.
LetiFend® enables the vaccination of a population of animals susceptible to catching the disease without compromising their subsequent serological diagnosis.
Recombinant technology: innovation in prevention
Recombinant vaccines are part of a new strategy and have been designed to ensure a targeted and effective immune response with a high level of safety.
More information
Bibliography
- Letifend®: EPAR – Product Information (internet). European Medicines Agency. Available in: http://www.ema.europea.eu/en/medicines/veterinary/EPAR/letifend.
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- Cacheiro-Llaguno C, Parody N, Renshaw-Calderón A, Osuna C, Alonso C, Carnés J. Vaccination with LetiFend® reduces circulating immune complexes in dogs experimentally infected with L. infantum. Vaccine. 2020 Jan 22;38(4):890-896. doi: 10.1016/j.vaccine.2019.10.078. Epub 2019 Nov 6. PMID: 31706810.
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