PCR MDR-1 (sensitivity to ivermectin)
There are certain breeds in which the sensitivity to ivermectin and derivatives has been demonstrated. This sensitivity is due to the genetic mutation of the gene mdr-1, which causes the deficit of a glycoprotein which protects the organism from certain drugs.
A high percentage of golden retrievers are healthy carriers of a genetic defect which causes a change in a transglutaminase, which causes serious flaking symptoms.
In order to detect these mutations through a PCR is carried out from a blood sample without heparin.