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LetiKerato

For seborrhoeic, dry and flaky skin

The Kerato line contains gluconolactone in addition to other ingredients such as urea and salicylic, lactic, glycolic, citric, malic and tartaric acids, which possess keratolytic and keratoplastic properties to cleanse the skin and remove dead cells.

Gluconolactone

The most important active substance is gluconolactone, with several beneficial effects for the skin:

Keratolytic

Removes the remains of dead cells in the stratum corneum. Exfoliating effect (1).

Keratoplastic

Promotes the reconstruction of the epidermal barrier and the production of lipids in the skin (2).

Moisturising

Attracts and incorporates water molecules in the epidermis, creating a protective film on the skin (3).

Antioxidant

Traps and scavenges free radicals, protecting against the harmful effects of UV radiation. (4).

Antimicrobial

Acidifies the stratum corneum, limiting microbial growth (5).

It is not an irritant, so it can even be used on animals with sensitive skin

Gluconolactone applied topically promotes the acidification of the stratum corneum, improves the action of ceramides, favors the maturation of the lipids of the epidermis and increases the cohesion between corneocytes, enhancing the barrier effect.

Kerato Shampoo
Formula PLUS

  • Indication: Quick and effective cleansing and moisturising of flaking associated with acute and severe keratoseborrhoeic disorders.
  • Use: Apply for 1–2 weeks (2 times/week) until improvement of symptoms.
  • 200 ml

Kerato Shampoo
Maintenance formula

  • Indication: Cleansing and moisturising of dry, slightly flaky skin.
  • Use: Apply once a week until total remission of clinical symptoms and even thereafter, to maintain the skin’s physiological conditions.
  • 500 ml

Kerato Lotion

  • Indication: Deep moisturisation for dry, flaky skin.
  • Use: Apply after washing or between washes. Its concentrated formula intensifies the effects of the shampoo.
  • 200 ml

Kerato Balm
Repair balm

  • Indication: Reduced nasal and plantar dryness and hyperkeratosis.
  • Use: Apply twice a day the first 15 days and then once a day for a further 7 days.
    After the area becomes normal, apply preventively 2–3 times per week.
  • 50 ml

Bibliography

  1. Berardesca E, Distante F, Vignoli GP, Oresajo C, Green B. Alpha hydroxyacids modulate stratumcorneumbarrierfunction. Br J Dermatol 1997;137:934-938.
  2. Hachem JP, Roelandt T, Schürer N, Pu X, Fluhr J, Giddelo C, Man M-Q, Crumrine D, Roseeuw D, Feingold KR, Mauro T, Elias PM. Acute acidification of stratum corneum membrane domains using polyhydroxyl acids improves lipid processing and inhibits degradation of corneodesmosomes. J Invest Dermatol. 2010;130:500-10.
  3. National Center for Biotechnology Information. PubChem Compound Database; CID=7027, https://pubchem.ncbi.nlm.nih.gov/compound/7027.
  4. Bernstein EF, Brown DB, Schwartz MD, Kaidbey K, Ksenzenko SM. The polyhydroxy acid gluconolactone protects against ultraviolet radiation in an in vitro model of cutaneous photoaging. Dermatol Surg. 2004;30:189-196.
  5. Chan A, Mauro T. Acidification in the epidermis and the role of secretory phospholipases. Dermatoendocrinol. 2011;3:84-90.
  6. Puigdemont A, Furiani N, De Lucia M, Carrasco I, Ordeix L, Fondevila D, Ramió-Lluch L, Brazis P. Topical polyhydroxy acid treatment for autosomal recessive congenital ichthyosis in the golden retriever: a prospective pilot study. Vet Dermatol. 2018; 29: 323-e113. May 22. doi: 10.1111/vde.12654. Download article
  7. Carrasco I, Puigdemont A, Ramió-Lluch L, de Lucía M, Furiani N, Ordeix L, Brazís P. Eficacia de una terapia tópica, con polihidroxiácidos, en la ictiosis del Golden retriever: estudio prospectivo. Poster. 16th Congreso de Especialidades Veterinarias GTA/AVEPA. Bilbao (Spain) 2017. Download poster
  8. Arrizabalaga A, Pol G.  Dermatosis seborreica del borde auricular en tres perros de raza Chihuahua y resolución con gluconolactona y urea. Poster. 16th Congreso de Especialidades Veterinarias GTA/AVEPA. Bilbao (Spain) 2017. Download poster
  9. Puigdemont A, Furiani N, Fondevila D, Ramió-Lluch L, Brazís P. Polyhydroxy acid-based topical treatment for ichthyosis in the golden retriever: histopathological findings. Poster. North American Veterinary Dermatology Forum (NAVDF). Maui, Hawaii. (USA). 2018. Abstract published in: VetDermatol 2018; 29: 287. Download poster